反应 #2460346

反应方程式

Methyl-3-aminopyrazine-2-carboxylate

Diisobutylaluminum hydride

→

title compound

收率 34.0%

3-aminopyrazine-2-carbaldehyde

收率 34.0%

溶剂

THF

反应条件

后处理

1. 1
   温度The reaction was then warmed to 0° C. for one hour
2. 2
   其他before being quenched slowly by addition of 1M hydrochloric acid
3. 3
   workup.ADDITIONEthyl acetate was added
4. 4
   其他the layers separated
5. 5
   干燥The organic layer was dried over magnesium sulfate
6. 6
   过滤filtered
7. 7
   浓缩concentrated
8. 8
   其他The residue was triturated in hexanes

实验过程

Methyl-3-aminopyrazine-2-carboxylate (11 g) was dissolved in THF and cooled to −78° C. Diisobutylaluminum hydride (1M in hexanes, 250 mL) was added, and the reaction stirred at −78° C. for 4 hours. The reaction was then warmed to 0° C. for one hour before being quenched slowly by addition of 1M hydrochloric acid. Ethyl acetate was added and the layers separated. The organic layer was dried over magnesium sulfate, filtered and concentrated. The residue was triturated in hexanes to afford title compound (3.0 g, 34%).

来源