反应 #2460344

反应方程式

4Methoxy-3-nitropyridine hydrochloride

ethylamine

→

title compound

收率 96.0%

Ethyl-(3-nitropyridin-4-yl)amine

收率 96.0%

溶剂

ethanol

water

反应条件

后处理

1. 1
   温度heated
2. 2
   温度under reflux for 2 hours
3. 3
   其他the solvent was removed in vacuo
4. 4
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
5. 5
   萃取The mixture was extracted (×3) with ethyl acetate
6. 6
   洗涤washed with water and saturated aqueous sodium chloride solution
7. 7
   干燥before drying over magnesium sulfate
8. 8
   其他Evaporation of the solvent

实验过程

4Methoxy-3-nitropyridine hydrochloride (11.2 g, 58.9 mmol) in ethanol (75 ml) was treated with a 70% solution of ethylamine in water (64 ml) and heated under reflux for 2 hours. After cooling to room temperature, the solvent was removed in vacuo and the residue dissolved in ethyl acetate and water. The mixture was extracted (×3) with ethyl acetate, washed with water and saturated aqueous sodium chloride solution before drying over magnesium sulfate. Evaporation of the solvent afforded the title compound (11.7 g, 96%).

来源