反应 #2460340

反应方程式

olanzapine

sulfuric acid

→

Olanzapine Hydrogensulfate

溶剂

acetone

acetone

反应条件

后处理

1. 1
   其他The formed crystals were isolated by filtration
2. 2
   洗涤washed with 20 ml of acetone and 20 ml of ether
3. 3
   其他dried overnight at 40° C. in vacuo

实验过程

To a solution of 5.0 g olanzapine base in 150 ml acetone was added at room temperature 0.435 ml of 95% sulfuric acid. The mixture was stirred overnight at 4° C. The formed crystals were isolated by filtration, washed with 20 ml of acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 5.87 g (approx. 0.25 eq. acetone present).

来源