反应 #2460338

ord-42eb0222d0924b0c86fd851cbf3ed77e

反应方程式

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
CCS(=O)(=O)O
ethane sulfonic acid
→
CCS(=O)(=O)[O-].Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
Olanzapine Esylate

反应物

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
CCS(=O)(=O)O
ethane sulfonic acid

试剂

无

溶剂

CC(C)=O
acetone
CC(C)=O
acetone

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他to form
  2. 2
    其他the crystals were isolated by filtration
  3. 3
    洗涤washed with 50 ml acetone

实验过程

To a solution of 5.0 g of olanzapine base in 150 ml acetone was added 1.76 g ethane sulfonic acid in 50 ml acetone at room temperature. Immediately a solid started to form. After stirring for 3 hours, the crystals were isolated by filtration and washed with 50 ml acetone. Yield: 6.59 g (97%).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07459449B2uspto-grants-2008_12