反应 #2460336

反应方程式

olanzapine

acetic acid

→

Olanzapine Acetate

溶剂

acetone

反应条件

后处理

1. 1
   其他The crystals were isolated by filtration
2. 2
   洗涤washed with 20 ml acetone and 20 ml of ether
3. 3
   其他dried overnight at 40° C. in vacuo

实验过程

To a solution of 5.0 g of olanzapine base in 150 ml acetone was added slowly 1.o6 g of acetic acid at room temperature and the mixture was stirred overnight at 4° C. The crystals were isolated by filtration, washed with 20 ml acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 3.32 g (56%).

来源