反应 #2460335
ord-2c52ce0473ba490ba0fc185ddb73e220
反应条件
详细条件
See reaction.notes.procedure_details.
后处理
- 1其他The formed crystals were isolated by filtration
- 2其他dried overnight at 40° C. in vacuo
- 3其他Isolated yield: 84.1 gram (90%)
实验过程
To a clear solution of 75 g olanzapine free base in 1500 ml acetone, was added slowly 18.0 g glycolic acid in 100 ml acetone at room temperature. The resulting mixture was stirred at room temperature overnight. The formed crystals were isolated by filtration and dried overnight at 40° C. in vacuo. Isolated yield: 84.1 gram (90%). 1H-NMR confirms the molar ratio olanzapine:acid=1:1.