反应 #2460334

反应方程式

olanzapine

glycolic acid

→

Olanzapine Glycolate

溶剂

acetone

acetone

反应条件

后处理

1. 1
   其他The crystals were isolated by filtration
2. 2
   洗涤washed with 15 ml of acetone and 20 ml of ether
3. 3
   其他dried overnight at 40° C. in vacuo

实验过程

To a solution of 5.0 g of olanzapine in 150 ml of acetone was added 1.22 g of glycolic acid in 25 ml acetone slowly at room temperature. The mixture was stirred overnight at 4° C. The crystals were isolated by filtration, washed with 15 ml of acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 5.76 g

来源