反应 #2460333

ord-061c37941fa74cd89611d45c26e6b4de

试剂

反应条件

温度
-20°CELSIUS
详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他the solid was isolated

实验过程

To a clear solution of 5.0 g of olanzapine base in 150 ml acetone was added, at room temperature, a solution of 1.44 g of L-(+)-lactic acid in 50 ml of acetone. The reaction mixture was stirred at −20° C. and the solid was isolated. Yield: 3.36 g (52%).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07459449B2uspto-grants-2008_12