反应 #2460330

反应方程式

olanzapine

benzoic acid

→

Olanzapine Benzoate

溶剂

acetone

acetone

反应条件

后处理

1. 1
   其他the crystals were isolated by filtration
2. 2
   洗涤washed with acetone (20 ml)
3. 3
   其他dried overnight at 40° C

实验过程

To a clear solution of olanzapine free base (5.0 g) in acetone (150 ml) was added slowly a solution of 1.0 equivalent of benzoic acid (1.96 g) in acetone (20 ml) at room temperature. After stirring at 4° C. overnight, the crystals were isolated by filtration, washed with acetone (20 ml) and dried overnight at 40° C. Yield: 6.23 g (90%).

来源