反应 #2460300

反应方程式

4-iodobenzoic acid

thiosalicylic acid

→

2,4′-thiobis(benzoic acid)

溶剂

sodium hydroxide

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux for 5 h
3. 3
   温度cooled
4. 4
   过滤The reaction mixture was filtered
5. 5
   其他The precipitate was collected
6. 6
   洗涤washed with water
7. 7
   workup.DISSOLUTIONdissolved
8. 8
   过滤filtered
9. 9
   浓缩The filtrate was concentrated

实验过程

First, 2,4′-thiobis(benzoic acid) was prepared. A mixture of 4-iodobenzoic acid (55.7 g, 225 mmol), thiosalicylic acid (34.6 g, 225 mmol), copper powder (15 g, 236 mmol), zinc powder (3 g, 46 mmol), and 2.5 M aqueous sodium hydroxide (400 mL) was heated at reflux for 5 h and then cooled to ambient. The reaction mixture was filtered, and the filtrate was acidified with concentrated HCl. The precipitate was collected and washed with water, then dissolved and filtered. The filtrate was concentrated to deposit 2,4′-thiobis(benzoic acid), mass 50 g (81% of theory).

来源