反应 #2460284

反应方程式

4-Bromophenol

potassium carbonate

benzyl bromide

→

4-benzyloxybromobenzene

溶剂

water

acetone

ethyl acetate

反应条件

后处理

1. 1
   温度The reaction was refluxed under nitrogen
2. 2
   温度After 5-6 hours of reflux
3. 3
   其他the organic layer was separated
4. 4
   干燥dried over magnesium sulfate
5. 5
   其他evaporated to dryness
6. 6
   其他to afford a white fluffy powder

实验过程

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5-6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

来源