反应 #2446112

ord-1a9e4f48a67d40b2b45543bd010484ec

反应方程式

COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride
→
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
oxycodone
收率 93.0%

反应物

COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride

试剂

无

溶剂

ClC(Cl)Cl
chloroform

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    洗涤washed with 5% aq. NaHCO3 (50 mL)
  2. 2
    干燥The organic layer was dried over MgSO4
  3. 3
    其他evaporated
  4. 4
    其他The residue was dried under vacuum overnight

实验过程

Oxycodone hydrochloride (10.0 g, 28.5 mmol) was dissolved in chloroform (150 mL) and washed with 5% aq. NaHCO3 (50 mL). The organic layer was dried over MgSO4 and evaporated. The residue was dried under vacuum overnight to provide oxycodone free base (8.3 g, 93%) as a white solid.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08685916B2uspto-grants-2014_04