反应 #2446080

反应方程式

tert-butyl cyclohexyl(2-hydroxypropyl)carbamate

2,4,6-trimethyl-benzoyl chloride

→

1-((tert-butoxycarbonyl)(cyclohexyl)amino)propan-2-yl 2,4,6-trimethylbenzoate

溶剂

ethyl acetate

toluene

反应条件

后处理

1. 1
   其他The resultant reaction mixture
2. 2
   洗涤washed with water and brine
3. 3
   干燥The organic layer was dried over sodium sulphate
4. 4
   浓缩concentrated to dryness

实验过程

To a solution of tert-butyl cyclohexyl(2-hydroxypropyl)carbamate (1 g, 3.89 mmol) in dry toluene (10 ml), 2,4,6-trimethyl-benzoyl chloride (0.510 mL, 4.280 mmol) was added. The resultant reaction mixture was stirred at rt for 16 hours. The reaction mixture was diluted in ethyl acetate and washed with water and brine. The organic layer was dried over sodium sulphate, and concentrated to dryness to obtain 1-((tert-butoxycarbonyl)(cyclohexyl)amino)propan-2-yl 2,4,6-trimethylbenzoate. Yield: 1 g (64.10%); LCMS: m/z=404.4 [M+H], RT=2.76 min, (Column: Y, Program: P1)

来源