反应 #2410

反应方程式

2-(6-aminopyrimidin-4-yloxy)ethanol

bromine

→

2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol

收率 104.7%

溶剂

methanol

methanol

反应条件

后处理

1. 1
   其他The mixture is evaporated
2. 2
   其他to remove the solvent
3. 3
   workup.DISSOLUTIONthe residue is dissolved in ethyl acetate
4. 4
   workup.ADDITIONThe mixture is treated with saturated aqueous sodium hydrogen carbonate solution
5. 5
   萃取extracted with ethyl acetate/tetrahydrofuran
6. 6
   洗涤The organic layer is washed
7. 7
   其他dried
8. 8
   其他evaporated
9. 9
   其他to remove the solvent

实验过程

To a suspension of 2-(6-aminopyrimidin-4-yloxy)ethanol (400 mg) in methanol (4 ml) is added dropwise a solution of bromine (437 mg) in methanol (2 ml). The mixture is evaporated to remove the solvent, and the residue is dissolved in ethyl acetate. The mixture is treated with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate/tetrahydrofuran. The organic layer is washed, dried, and evaporated to remove the solvent to give 2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol (632 mg).

来源