反应 #2407

反应方程式

4,6-dichloropyrimidine

ethylene glycol

sodium hydride

→

2-(6-chloropyrimidin-4-yloxy)ethanol

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   温度cooling
2. 2
   其他evaporated
3. 3
   其他to remove the solvent
4. 4
   萃取The residue is extracted with ethyl acetate
5. 5
   萃取the ethyl acetate extract
6. 6
   其他is dried
7. 7
   浓缩concentrated under reduced pressure
8. 8
   其他The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1)

实验过程

To a mixture of 4,6-dichloropyrimidine (5.0 g), ethylene glycol (100 ml) and tetrahydrofuran (100 ml)is added sodium hydride (60% dispersion-type, 1.34 g) under ice-cooling. The mixture is stirred at the same temperature for two hours, and evaporated to remove the solvent. The residue is extracted with ethyl acetate, and the ethyl acetate extract is dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1) to give 2-(6-chloropyrimidin-4-yloxy)ethanol (5.67 g) as an oily product.

来源