反应 #2404

反应方程式

4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide

sodium hydride

ethylene glycol

hydrochloric acid

→

4-tert-butyl-N-{6-(2-hydroxyethoxy)pyrimidin-4-yl}benzenesulfonamide

反应条件

后处理

1. 1
   温度After cooling
2. 2
   萃取extracted with ethyl acetate
3. 3
   洗涤The ethyl acetate layer is washed
4. 4
   其他dried
5. 5
   其他evaporated
6. 6
   其他to remove the solvent
7. 7
   其他The residue is crystallized from ethyl acetate

实验过程

To ethylene glycol (20 ml) is added sodium hydride (60% dispersion-type, 1.03 g), and thereto is added 4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide (1.66 g). The mixture is stirred at 60° C. for 20 hours. After cooling, the mixture is acidified with 10% hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from ethyl acetate to give 4-tert-butyl-N-{6-(2-hydroxyethoxy)pyrimidin-4-yl}benzenesulfonamide (1.58 g).

来源