反应 #2401

反应方程式

ammonium chloride

6-chloro-5-(4-methylphenyl)pyrimidin-4-amine

sodium hydride

ethylene glycol

→

2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

反应条件

后处理

1. 1
   其他is reacted at 70° C. for two hours
2. 2
   其他reacted at 90° C. for five hours
3. 3
   萃取extracted with ethyl acetate
4. 4
   洗涤The ethyl acetate layer is washed
5. 5
   其他dried
6. 6
   其他evaporated
7. 7
   其他to remove the solvent
8. 8
   其他The residue is crystallized from hexane/ethyl acetate

实验过程

A mixture of 6-chloro-5-(4-methylphenyl)pyrimidin-4-amine (500 mg), ethylene glycol (10 ml) and sodium hydride (60% dispersion-type, 0.46 g) is reacted at 70° C. for two hours, and reacted at 90° C. for five hours. The mixture is treated with saturated aqueous ammonium chloride solution, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane/ethyl acetate to give 2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (422 mg).

来源