反应 #2399

反应方程式

2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

→

2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol

收率 89.7%

溶剂

ethanol

反应条件

后处理

1. 1
   其他is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere
2. 2
   其他for one hour
3. 3
   其他The catalyst is removed by filtration
4. 4
   浓缩the filtrate is concentrated under reduced pressure
5. 5
   其他The residue is recrystallized from ethyl acetate/n-hexane

实验过程

A mixture of 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (19.6 g), 10% palladium-carbon (50% moist) (4.0 g) and ethanol (240 ml) is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere (1 atm) for one hour. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is recrystallized from ethyl acetate/n-hexane to give 2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (15.9 g).

来源