反应 #2383806

反应方程式

2-hydroximinohomopiperidine

1,1′-carbonyldiimidazole

→

title compound

收率 89.2%

6,7,8,9-tetrahydro-3H,5H-[1,2,4]oxadiazolo[4,3-a]azepin-3-one

收率 89.2%

溶剂

CH2Cl2

methylene chloride

反应条件

后处理

1. 1
   洗涤washed with water
2. 2
   干燥dried (MgSO4)
3. 3
   过滤filtered
4. 4
   浓缩concentrated

实验过程

To a solution of 2 g (16 mmol) of 2-hydroximinohomopiperidine (Maybridge) in 20 mL of methylene chloride (CH2Cl2) was added 2.5 g (16 mmol) of 1,1′-carbonyldiimidazole (CDI). This was stirred at 25° C. for six days. This solution was diluted with CH2Cl2, washed with water, dried (MgSO4), filtered and concentrated to afford 2.2 g (89% yield) of the title compound as a white semi-solid. Mass Spectra for C7H10N2O2: M+H155. 1H NMR,(CDCl3) d 1.5-1.9 (m, 6H), 2.6 (dd, 2H), 3.6 (dd, 2H). 13C NMR (CDCl3) d 25.3, 26.0, 28.2, 30.2, 43.7, 159.1, 161.6.

来源