反应 #2383793

反应方程式

2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one

potassium nitrate

→

title compound

收率 22.2%

7-Nitro-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one

收率 22.2%

溶剂

sulfuric acid

反应条件

后处理

1. 1
   workup.WAITfor 4 h at room temperature
2. 2
   过滤the solids were collected by filtration
3. 3
   温度cooled

实验过程

To 2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one (30.34 g, 190 mmol) in conc. sulfuric acid (600 ml) at 0° C. was added potassium nitrate (20.82 g, 206 mmol) portionwise. The mixture was stirred for 20 minutes at 0° C. and then for 4 h at room temperature. The mixture was poured onto ice (21) and the solids were collected by filtration. The solids were taken up in hot ethyl acetate and then cooled to yield the title compound (8.79 g, 22%), MS m/z 209 [M+H]+.

来源