反应 #2383792

反应方程式

ammonium hydroxide

4-chromanone

sodium azide

sulfuric acid

→

2,3,4,5-Tetrahydro-1,4-benzoxazepin-5-one

溶剂

acetic acid

反应条件

后处理

1. 1
   温度cooled to room temperature
2. 2
   workup.ADDITIONThe mixture was poured onto ice (1 l)
3. 3
   过滤the solids were collected by filtration (30.43 g, 55%), MSm/z 164 [M+H]+

实验过程

To 4-chromanone (50 g, 340 mmol) in acetic acid (670 ml) was added sodium azide (66.31 g, 1.02 mol) and conc. sulfuric acid (100 ml) dropwise at 0° C. The mixture was heated to 50° C. for 4 h and then cooled to room temperature. The mixture was poured onto ice (1 l) and basified with conc. ammonium hydroxide. The mixture was stirred for 24 h and the solids were collected by filtration (30.43 g, 55%), MSm/z 164 [M+H]+.

来源