反应 #2358561

反应方程式

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione

hydroxylamine hydrochloride

→

title compound

收率 85.3%

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-9-hydroxyimino-10-methyl-(9H,10H)-acridine

收率 85.3%

溶剂

pyridine

反应条件

后处理

1. 1
   其他Solvent was removed
2. 2
   workup.ADDITIONthe residue was treated with water
3. 3
   其他to remove excess of hydroxylamine
4. 4
   其他Crude material was crystallized from methanol-water

实验过程

To a solution of 2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione (290 mg, 0.5 mmole) in pyridine (5 mL) was added hydroxylamine hydrochloride (210 mg, 30 mmole) and the mixture was stirred at 100° C. for 8 hrs. Solvent was removed and the residue was treated with water to remove excess of hydroxylamine. Crude material was crystallized from methanol-water to give 245 mg (85%) of the title compound. MS 575 (MH+).

来源