反应 #2358560

反应方程式

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridin-9(10H)-one

compound 11-4

Lawesson's reagent

→

title compound

收率 86.8%

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione

收率 86.8%

溶剂

toluene

反应条件

后处理

1. 1
   温度was refluxed for 4 hrs
2. 2
   其他Toluene was removed by evaporation
3. 3
   workup.ADDITIONTo the residue methanol (20 mL) was added
4. 4
   过滤the product was collected by filtration
5. 5
   其他dried

实验过程

A mixture of compound 11-4 (560 mg, 1 mmole), anhydrous toluene (10 mL) and Lawesson's reagent (820 mg, 2 mmole) was refluxed for 4 hrs. Toluene was removed by evaporation. To the residue methanol (20 mL) was added, stirred for few minutes at room temperature and the product was collected by filtration and dried to give 500 mg of the title compound. MS 576 (MH+).

来源