反应 #2358546

ord-19dbae17107043ed8066efde800e1aae

反应方程式

COC(=O)c1cccc(OCc2ccccc2)c1OCc1ccccc1
nitroaniline
COC(=O)c1cccc(OCc2ccccc2)c1OCc1ccccc1
Bis-benzyloxy benzoic acid methyl ester
CCC(=O)Cl
propionyl chloride
O=C(O)c1cccc(OCc2ccccc2)c1OCc1ccccc1
nitro-phenyl-propionamide
O=C(O)c1cccc(OCc2ccccc2)c1OCc1ccccc1
Bis-benzyloxy benzoic acid

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他In another embodiment the compounds can be prepared

实验过程

In another embodiment the compounds can be prepared as shown in Scheme III. A nitroaniline (1) can be reacted with propionyl chloride to yield nitro-phenyl-propionamide (2). NaH can then be added to a solution of (2) in anhydrous THF followed by iodomethane to give pure product nitro-phenyl-N-methyl-propionamide (3).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09120745B2uspto-grants-2015_09