反应 #2358525

反应方程式

tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate

HCl

NaOH

→

title compound

收率 78.6%

2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethanamine

收率 78.6%

溶剂

EtOH

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate (2×100 ml)
2. 2
   洗涤The combined organic phase was washed with brine (75 ml)
3. 3
   干燥dried (Na2SO4)
4. 4
   其他evaporated

实验过程

A mixture of tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate (1.4 g, 4.2 mmol) in EtOH (18 ml) was added HCl (1.25 M in EtOH, 6 ml). The mixture was stirred at ambient temperature for 20 h. The aqueous phase was made basic by addition of aqueous NaOH (1 M, 50 ml) and extracted with ethyl acetate (2×100 ml). The combined organic phase was washed with brine (75 ml), dried (Na2SO4) and evaporated to yield the title compound (0.77 g, 77%). MS m/z (relative intensity, 70 eV 298 (M+, 18), 296 (M+, 18), 109 (bp), 107 (99), 82 (15).

来源