反应 #2358517

反应方程式

hydrochloric acid

1-(2-bromoethoxy)-3-chloro-5-methylsulfonyl-benzene

propane-1-amine

→

N-[2-(3-chloro-5-methylsulfonyl-phenoxy)ethyl]propan-1-amine

溶剂

ethanol

反应条件

后处理

1. 1
   其他Preparation
2. 2
   其他re-crystallized from ethanol/diethyl ether

实验过程

Preparation according to Example 1 but performed in one portion: 1-(2-bromoethoxy)-3-chloro-5-methylsulfonyl-benzene (0.5 g, 1.59 mmol) and propane-1-amine (1.04 ml, 12.76 mmol) in ethanol (5 ml). Yield: 368 mg (79.1%). The amine was converted to the hydrochloric acid salt and re-crystallized from ethanol/diethyl ether: M.p. 195-197° C. MS m/z (relative intensity, 70 eV) 291 (M+, 1), 264 (8), 262 (22), 73 (9), 72 (bp).

来源