反应 #2358487

反应方程式

2-fluoro-6-(trifluoromethyl)benzaldehyde

methyl thioglycolate

potassium carbonate

DMF

→

methyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

收率 35.4%

溶剂

water

反应条件

后处理

1. 1
   温度The reaction mixture was cooled to room temperature
2. 2
   萃取extracted with tert-butyl methyl ether 3 times
3. 3
   洗涤The combined organic layer was washed with water
4. 4
   干燥The mixture was dried over magnesium sulfate
5. 5
   浓缩concentrated under reduced pressure

实验过程

A mixture of 1.00 g of 2-fluoro-6-(trifluoromethyl)benzaldehyde, 633 mg of methyl thioglycolate, 1.21 g of potassium carbonate and 15 ml of DMF was stirred at 130° C. for 2 hours. The reaction mixture was cooled to room temperature. To the reaction mixture was added water, and then extracted with tert-butyl methyl ether 3 times. The combined organic layer was washed with water, followed by saturated aqueous sodium chloride solution. The mixture was dried over magnesium sulfate, and then concentrated under reduced pressure to obtain 480 mg of methyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate (the present compound 3).

来源