反应 #2358149

反应方程式

dimethylacetamide

phosphorus oxychloride

NaOH

2-benzylindole

→

titled compound

收率 53.0%

3-Acetyl-2-benzylindole

收率 53.0%

反应条件

后处理

1. 1
   其他prepared in accordance with the literature (Khim.Geterotsikl.Soedin.1994,p133))
2. 2
   workup.STIRRINGAfter stirring for 2 hours at 100° C.
3. 3
   萃取extracted with ethyl acetate
4. 4
   洗涤The extract was washed with water
5. 5
   其他dried
6. 6
   浓缩concentrated
7. 7
   洗涤The obtained crystal was washed with n-hexane

实验过程

To a solution of 29.5 g (39 mmol) of dimethylacetamide was added dropwise under ice-cooling 7.00 g (76.9 mmol) of phosphorus oxychloride. After stirring for 30 min at room temperature, to the mixture was added 8.00 g (38.6 mmol) of 2-benzylindole (prepared in accordance with the literature (Khim.Geterotsikl.Soedin.1994,p133)). After stirring for 2 hours at 100° C., the mixture was poured to ice-water, neutralized with 2N NaOH, extracted with ethyl acetate. The extract was washed with water, dried, and concentrated. The obtained crystal was washed with n-hexane to give 5.1 g of the titled compound. Yield: 52%.

来源