反应 #2353

反应方程式

ε-caprolactone

L-lactide

glycerol

stannous octoate

→

ε-CAPROLACTONE L-LACTIDE

溶剂

toluene

反应条件

后处理

1. 1
   其他A flame dried
2. 2
   其他The flask was fitted with a flame
3. 3
   其他dried mechanical stirrer
4. 4
   其他The reactor was purged with nitrogen three times
5. 5
   温度maintained at this temperature for about 18-20 hours
6. 6
   其他The copolymer was dried under vacuum (0.1 mm Hg) at 110° C. for about 16 hours
7. 7
   其他to remove any unreacted monomer
8. 8
   其他at 25° C
9. 9
   其他at room temperature

实验过程

A flame dried, 250 mL, round bottom single neck flask was charged with 57.1 grams (0.50 mole) of ε-caprolactone, 72.1 grams (0.50 mole) of L-lactide, 4.00 mL (55 mmol) of distilled glycerol, and 0.10 mL (34 μmol) of a 0.33M stannous octoate solution in toluene. The flask was fitted with a flame dried mechanical stirrer. The reactor was purged with nitrogen three times before venting with nitrogen. The reaction mixture was heated to 160° C. and maintained at this temperature for about 18-20 hours. The copolymer was dried under vacuum (0.1 mm Hg) at 110° C. for about 16 hours to remove any unreacted monomer. The copolymer had an inherent viscosity of 0.14 dL/g in hexafluoroisoproponal (HFIP) at 25° C. The copolymer was a liquid at room temperature. The molar ratio of PCL/PLA was found to be 53.7/46.3 by proton NMR.

来源