反应 #2348125

反应方程式

3-methoxythioanisole

oxone

acetone

→

1-methanesulfonyl-3-methoxy benzene

收率 98.0%

溶剂

water

反应条件

后处理

1. 1
   其他resulting in the formation of a white precipitate
2. 2
   过滤the solid was filtered off
3. 3
   洗涤washed with acetone
4. 4
   浓缩Filtrate was concentrated
5. 5
   其他to remove acetone
6. 6
   萃取Aqueous layer was extracted with EtOAc (2×200 mL)
7. 7
   干燥dried over Na2SO4
8. 8
   其他The solvent was removed

实验过程

To a solution of 3-methoxythioanisole (3.084 g, 20 mmol) in 300 mL acetone was added a solution of oxone (30.74 g, 50 mmol) in 125 mL water, resulting in the formation of a white precipitate. Stirring continued overnight, and the solid was filtered off and washed with acetone. Filtrate was concentrated to remove acetone. Aqueous layer was extracted with EtOAc (2×200 mL) and dried over Na2SO4. The solvent was removed to give 1-methanesulfonyl-3-methoxy benzene (3.68 g, 98%) as oil.

来源