反应 #2336

反应方程式

1-(4-aminophenyl)-4-(4-pyridyl)piperazine

succinic anhydride

DMF

→

title compound

4-oxo-4-[4-[4-(4-pyridyl)piperazin-1-yl]-phenyl]-aminobutyric acid

反应条件

后处理

1. 1
   其他a precipitate was collected
2. 2
   洗涤washed with DMF and ethanol
3. 3
   其他dried

实验过程

To a solution of 1-(4-aminophenyl)-4-(4-pyridyl)piperazine (100 mg) in DMF (8 ml) was added succinic anhydride (79 mg). The reaction mixture was stirred at room temperature for 2.5 hr and a precipitate was collected, washed with DMF and ethanol, then dried to give the title compound (106 mg) as a beige-coloured solid: m.p. 263°-264° C.; NMR (d6 -DMSO+CF3CO2H) δ 2.68 (4H, m), 3.80 (4H, m), 4.19 (4H, m), 7.20 (2H, d), 7.56 (2H, d), 7.82 (2H, d), 8.21 (2H, d), 9.62 (1H, s); m/Z 355 (M+H)+ ; calculated for C19H22N4 O3. 0.4 H2O: C, 63.1%; H, 6.36%; N, 15.5%; found: C, 63.1%; H, 6.4%; N, 15.7%.

来源