反应 #2329004

反应方程式

4-{[(6-methoxypyridin-3-yl)methylene]amino}benzene-1,3-diol

DDQ

→

title compound

2-(6-Methoxypyridin-3-yl)-1,3-benzoxazol-6-ol

溶剂

CH2Cl2

反应条件

后处理

1. 1
   workup.ADDITIONSiO2 was added
2. 2
   其他the solvents were removed under reduced pressure
3. 3
   其他The crude product was purified by flash column chromatography

实验过程

4-{[(6-methoxypyridin-3-yl)methylene]amino}benzene-1,3-diol was dissolved in CH2Cl2 (30 mL) and DDQ was added. The reaction mixture was stirred over night at r.t., SiO2 was added and the solvents were removed under reduced pressure. The crude product was purified by flash column chromatography to give the title compound (189.1 mg). 1H NMR δ ppm 9.88 (s, 1H) 8.90 (dd, 1H) 8.35 (dd, 1H) 7.56 (d, 1H) 7.09 (d, 1H) 6.85 (dd, 1H) 3.95 (s, 3H); MS m/z 243 (M+H).

来源