反应 #2328999

ord-aaf3928a1d974a22bbba1517cecdc132

反应方程式

COc1ccc2nc(-c3ccc(NC(=O)OC(C)(C)C)nc3)oc2c1
tert-butyl [5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-yl]carbamate
COc1ccc2nc(-c3cnc(N)nc3)oc2c1
5-(6-methoxy-1,3-benzoxazol-2-yl)pyrimidin-2-amine
COc1ccc2nc(-c3cnc(NC(=O)OC(C)(C)C)nc3)oc2c1
title intermediate
COc1ccc2nc(-c3cnc(NC(=O)OC(C)(C)C)nc3)oc2c1
tert-Butyl [5-(6-methoxy-1,3-benzoxazol-2-yl)pyrimidin-2-yl]carbamate

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他to give 115 mg

实验过程

The title intermediate was synthesized from 5-(6-methoxy-1,3-benzoxazol-2-yl)pyrimidin-2-amine according to the procedure described for tert-butyl [5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-yl]carbamate to give 115 mg. 1H NMR 400 MHz, Chloroform-d) δ ppm 9.33 (s, 2H) 8.17 (s, 1H) 7.65 (d, 1H) 7.14 (d, 1H) 7.00 (dd, 1 H) 3.90 (s, 3H) 1.60 (s, 9H). MS m/z 343 (M+H).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07670591B2uspto-grants-2010_03