反应 #2328975

反应方程式

trans-4-vinyl cyclohexane carboxylic acid

trimethylsilyl chloride

→

methyl trans-4-vinylcyclohexanecarboxylate

溶剂

methanol

反应条件

后处理

1. 1
   温度by refluxing for 6 hours
2. 2
   浓缩concentrated under reduced pressure
3. 3
   workup.ADDITION150 mL of hexane was added
4. 4
   其他the methanol layer was separated
5. 5
   萃取the methanol layer was extracted with hexane
6. 6
   洗涤the mixture was washed with saturated saline
7. 7
   干燥The organic layer was dried over anhydrous sodium sulfate
8. 8
   浓缩concentrated

实验过程

All of trans-4-vinyl cyclohexane carboxylic acid was dissolved in 120 mL of methanol and 0.1 g of trimethylsilyl chloride was added, followed by refluxing for 6 hours. The solution was cooling to room temperature and then concentrated under reduced pressure. 150 mL of hexane was added and the methanol layer was separated, and then the methanol layer was extracted with hexane. After combining with the organic layer, the mixture was washed with saturated saline. The organic layer was dried over anhydrous sodium sulfate and then concentrated to obtain 29.5 g of methyl trans-4-vinylcyclohexanecarboxylate.

来源