反应 #2325

反应方程式

Charcoal

product

4-acetylamino-1-benzylpiperidine

hydrochloric acid

hydrogen

→

4-acetylaminopiperidine hydrochloride

溶剂

methanol

反应条件

后处理

1. 1
   其他hydrogenated at room temperature
2. 2
   过滤then filtered through diatomaceous earth
3. 3
   其他the filtrate evaporated to dryness

实验过程

10% w/w Palladium on charcoal (1.5 g) was added to a solution of the product from step (i) (10.0 g), 1 molar hydrochloric acid (21.5 ml) and methanol (150 ml) and the mixture hydrogenated at room temperature and pressure until the theoretical amount of hydrogen had been taken up. Charcoal was added, the mixture stirred for 1 hour then filtered through diatomaceous earth and the filtrate evaporated to dryness giving 4-acetylaminopiperidine hydrochloride, 8.64 g, as a sticky foam: NMR (CDCl3 +d6DMSO). δ 9,72(1H,b), 9.02(1H,b), 7.40(1H,bd), 3.87(1H,m), 3.30(2H,m), 2.81(2H,m), 1.86(4H,m), 1.80(3H,s); m/e 143 (M+H)+.

来源