反应 #2320174

反应方程式

8-bromo-7-fluoro-2-(methyloxy)-1,5-naphthyridine

potassium carbonate

DME

→

solid

收率 90.0%

8-ethenyl-7-fluoro-2-(methyloxy)-1,5-naphthyridine

收率 90.0%

溶剂

H2O

反应条件

后处理

1. 1
   其他the reaction contents
2. 2
   浓缩were concentrated
3. 3
   其他the product purified by chromatography (silica, 25% EtOAc in hexane)

实验过程

To a solution of 8-bromo-7-fluoro-2-(methyloxy)-1,5-naphthyridine (2.0 g, 7.81 mmol), potassium carbonate (1.08 g, 7.81 mmol), tetrakis-triphenylphosphine (90 mg, 0.08 mmol) in DME (60 mL) and H2O (20 mL) was added 2,4,6-trivinylcycloborane-pyridine complex (0.94 g, 3.91 mmol). After stirring for 10 h at 85° C. the reaction contents were concentrated and the product purified by chromatography (silica, 25% EtOAc in hexane) to give a low melting solid (1.43 g, 90%).

来源