反应 #2320168

反应方程式

5-amino-2-methoxypyridine

diethyl ethoxymethylenemalonate

→

title compound

收率 100.3%

2-[(6-Methoxypyridin-3-ylamino)methylene]malonic acid diethyl ester

收率 100.3%

溶剂

EtOH

反应条件

后处理

1. 1
   温度at reflux for 4 h
2. 2
   浓缩Concentration to dryness

实验过程

A solution of 5-amino-2-methoxypyridine (Aldrich, 100 g, 0.806 mole) and diethyl ethoxymethylenemalonate (Aldrich, 163 mL, 0.806 mole) in EtOH (1 L) was heated at reflux for 4 h, then was cooled to RT. Concentration to dryness gave the title compound (238 g, quantitative).

来源