反应 #2320158

反应方程式

solution

2-(Pyridin-3-yloxy)-benzonitrile

→

title compound

2-(Pyridin-3-yloxy)-benzylamine

溶剂

NH3

methanol

反应条件

后处理

1. 1
   过滤the reaction mixture was filtered through a micro pore
2. 2
   过滤filter
3. 3
   浓缩concentrated

实验过程

To a solution of Example 94A (4.28 g, 21.84 mmol) in 7N NH3 in methanol (200 ml) was added Raney nickel (12 g) under argon atmosphere. The reaction mixture was kept on a shaker under 60 psi H2 atmosphere. After 6 hours at room temperature, the reaction mixture was filtered through a micro pore filter and concentrated to give the title compound. MS (ESI+) m/z 201 (M+H)+.

来源