反应 #2320152

反应方程式

2-o-tolylacetamide

N,N,-dimethylformamide dimethylacetal

N,N,-dimethylformamide dimethylacetal

→

title compound

N-formyl-2-(o-methylphenyl)acetamide

溶剂

acetic acid

反应条件

后处理

1. 1
   workup.STIRRINGstirred at 0° C. for 30 min
2. 2
   过滤The precipitate was filtered
3. 3
   洗涤washed with water
4. 4
   其他dried

实验过程

A mixture of 2-o-tolylacetamide (Lee, Dong-Ung; Mayer, Klaus K.; Wiegrebe, Wolfgang; Lauber, Rolf; Schlunegger, Urs P.; Arch. Pharm. 1988, 321; 265-272) (320 mg, 2.15 mmol) and N,N,-dimethylformamide dimethylacetal (1.1 mL, 8.59 mmol) was stirred under N2 for 55 min at 120° C. The excess of N,N,-dimethylformamide dimethylacetal was eliminated under reduced pressure. The residue was dissolved in 3 mL of 70% aqueous acetic acid and stirred at 0° C. for 30 min. The precipitate was filtered, washed with water and dried to afford the title compound as a white solid. MS (DCI/NH3) m/z 195 (M+NH4)+.

来源