反应 #2320133

反应方程式

4-bromophenylboronic acid

2-bromo-5-methylpyridine

potassium carbonate

1,2-dimethoxyethane

→

2-(4-bromophenyl)-5-methylpyridine

收率 91.9%

溶剂

water

ethyl acetate

water

反应条件

后处理

1. 1
   温度The mixture was heated
2. 2
   温度to reflux under nitrogen atmosphere for 18 hours
3. 3
   温度After the reaction was cooled down
4. 4
   其他The mixture was separated in a separatory funnel
5. 5
   其他The organic phases were collected
6. 6
   其他evaporated
7. 7
   workup.DISTILLATIONThe mixture was distilled

实验过程

To a 500 mL round bottom flask, 4-bromophenylboronic acid (25.0 g, 0.125), 2-bromo-5-methylpyridine (20.0 g, 0.114 mol), palladium(0)tetrakistriphenylphosphine (4.0 g, 0.0035 mol), potassium carbonate (47.0 g, 0.34 mol.), 1,2-dimethoxyethane (120 mL) and water (120 mL.) were added. The mixture was heated to reflux under nitrogen atmosphere for 18 hours. After the reaction was cooled down, 100 mL of water and 150 mL of ethyl acetate were added. The mixture was separated in a separatory funnel. The organic phases were collected, combined and evaporated. The mixture was distilled using a kugelrohred (spelling?) to obtain 2-(4-bromophenyl)-5-methylpyridine (26.0 g) as a white solid that was further purified by recrystallization in hexanes.

来源