反应 #2320128

反应方程式

magnesium dioxide

1-phenyl-4-methyl-3,4-dihydroisoquinoline

→

pure yellow crystals

收率 42.5%

1-phenyl-4-methylisoquinoline

收率 42.5%

溶剂

benzene

反应条件

后处理

1. 1
   温度The reaction mixture was heated
2. 2
   温度at reflux for 16 hours
3. 3
   其他The magnesium dioxide was removed by vacuum filtration
4. 4
   洗涤washed with methylene chloride
5. 5
   其他Evaporation of the solvent

实验过程

To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.

来源