反应 #2320127

反应方程式

1-amino-2-phenylpropane

triethylamine

benzoyl chloride

→

N-(2-phenylpropyl)benzamide

收率 95.0%

溶剂

chloroform

chloroform

反应条件

后处理

1. 1
   workup.ADDITIONAfter completion of the addition
2. 2
   温度the reaction mixture was heated
3. 3
   温度at reflux for 1 hour
4. 4
   洗涤The solution was then washed with water
5. 5
   干燥the organic layer dried over magnesium sulfate
6. 6
   其他Removal of the solvent

实验过程

To a solution of 1-amino-2-phenylpropane (25.0 g, 0.185 mol) and triethylamine (18.2 g, 0.185 mol) in 150 mL of chloroform was added dropwise, a solution of benzoyl chloride (26.0 g, 0.185 mol) in 150 mL of chloroform under nitrogen. After completion of the addition, the reaction mixture was heated at reflux for 1 hour. The solution was then washed with water and the organic layer dried over magnesium sulfate. Removal of the solvent yielded 42.0 g (95%) of N-(2-phenylpropyl)benzamide as a white powder.

来源