反应 #2320118

反应方程式

CH2Cl2

5-Bromo-2,4-difluoro-N,N-dimethyl-benzenesulfonamide

4-pyridine-boronic acid

Na2CO3

→

2,4-Difluoro-N,N-dimethyl-5-pyridin-4-yl-benzenesulfonamide

溶剂

toluene

反应条件

后处理

1. 1
   洗涤the organic phase was washed with water
2. 2
   干燥dried (MgSO4)
3. 3
   过滤filtered
4. 4
   其他evaporated to dryness
5. 5
   其他The residue was then used without any further purification

实验过程

5-Bromo-2,4-difluoro-N,N-dimethyl-benzenesulfonamide (400 mg) and 4-pyridine-boronic acid (165 mg) was dissolved in toluene (5 ml) and abs EtoH (5 ml). To the mixture was then added Na2CO3 (200 mg) and Pd(PPh3)4 (79 mg) under an atmosphere of Argon. The resulting mixture was heated to 90° C. for 18 h. Then CH2Cl2 was added and the organic phase was washed with water and dried (MgSO4), filtered and evaporated to dryness. The residue was then used without any further purification. (MS m/z (rel. intensity, 70 eV) 298 (M+, 77), 256 (36), 191 (bp), 190 (98), 143 (74).

来源