反应 #2320113

反应方程式

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol

trifluoroacetic acid

→

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

溶剂

CH2Cl2

反应条件

后处理

1. 1
   温度refluxed for 24 hours
2. 2
   其他The phases were separated
3. 3
   洗涤the organic phase was washed with two portions of 10%-Na2CO3
4. 4
   干燥dried (MgSO4)
5. 5
   过滤filtered
6. 6
   其他evaporated to dryness

实验过程

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol (1.5 g) was dissolved trifluoroacetic acid (35 ml) and refluxed for 24 hours and then CH2Cl2 (200 ml) was added. The phases were separated and then the organic phase was washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 1.5 g. MS m/z (relative intensity, 70 eV) 351 (M+, 27), 172 (9), 92 (11), 91 (bp), 65 (21).

来源