反应 #2314351

反应方程式

4,5-Dichloro-1,2-phenylenediamine

cyclopropyl isothiocyanate

1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate

→

yellow solid

收率 70.5%

2-(Cyclopropylamino)5,6-dichloro-1H-benzimidazole

收率 70.5%

溶剂

pyridine

反应条件

后处理

1. 1
   其他The product was recrystallized from acetonitrile

实验过程

4,5-Dichloro-1,2-phenylenediamine (6.04 g, 34.1 mmol), cyclopropyl isothiocyanate (3.69 g, 37.2 mmol), 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (20.1 g, 47.4 mmol) and pyridine (135 mL) were used according to general procedure I. The product was recrystallized from acetonitrile to afford 5.82 g (70%) of a yellow solid; m.p. 223-225° C. 1H NMR (DMSO-d6) δ: 11.2 (s, 1H, NH), 7.43 (s, 1H, NH), 7.27 (s, 2H, ArH), 2.49 (m, 1H, CH), 0.70 (m, 2H, CH), 0.49 (m, 2H, CH).

来源