反应 #2314344

反应方程式

ethyl 6-bromo-4-hydroxy-7-methyl[1,8]naphthyridine-3-carboxylate

4-chlorobenzylamine

→

6-bromo-N-(4-chlorobenzyl)-4-hydroxy-7-methyl[1,8]naphthyridine-3-carboxamide

溶剂

EtOAc

反应条件

后处理

1. 1
   温度The mixture is cooled
2. 2
   其他The resulting precipitate is collected
3. 3
   其他dried

实验过程

A solution of ethyl 6-bromo-4-hydroxy-7-methyl[1,8]naphthyridine-3-carboxylate (Prep 1 0.57 g) and 4-chlorobenzylamine (2.59 g) is heated to 180° C. for 1 h. The mixture is cooled and diluted with EtOAc. The resulting precipitate is collected and dried. Physical characteristics are as follows: m.p. 269-270° C.; 1H NMR (DMSO-d6) δ 13.21, 10.09, 8.67, 8.62, 7.38, 4.54, 2.71; IR (drift) 3028, 2974, 2907, 1653, 1598, 1555, 1526, 1493, 1410, 1354, 1326, 1242, 1096, 806, 639 cm−1; Anal. Calcd for C17H13BrClN3O2: C, 50.21; H, 3.22; N, 10.33; Found: C, 50.31; H, 3.23; N, 10.17.

来源