反应 #2314341

反应方程式

Water

N-[4-(hydroxymethyl)benzyl] 4-oxo-1,4-dihydro-quinoline-3-carboxamide

thionyl chloride

→

4-oxo-1,4-dihydro-quinoline-3-carboxamide

溶剂

brine

DMF

反应条件

后处理

1. 1
   其他the precipitate is collected
2. 2
   洗涤rinsed with a small quantity of methanol and ether
3. 3
   其他dried

实验过程

To a solution of N-[4-(hydroxymethyl)benzyl] 4-oxo-1,4-dihydro-quinoline-3-carboxamide (279 mg; 0.79 mmol) in anhydrous DMF (8 mL) at 0° is added thionyl chloride (61 μL; 0.83 mmol) and the solution is stirred at room temperature for 1 h. Water (10 mL) and brine (10 mL) are added, and the precipitate is collected, rinsed with a small quantity of methanol and ether, and dried to give 214 mg of N-[4-chloromethyl)benzyl] 4-oxo-1,4-dihydro-quinoline-3-carboxamide.

来源