反应 #2314339

反应方程式

ethyl 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylate

NaOH

HCl

→

6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

收率 87.4%

溶剂

ethanol

反应条件

后处理

1. 1
   温度is heated
2. 2
   温度at reflux for 1.5 h
3. 3
   温度The reaction mixture is cooled in an ice bath
4. 4
   其他the precipitate is collected
5. 5
   洗涤rinsed with water
6. 6
   其他dried

实验过程

A mixture of ethyl 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylate (1.22 g, 4.96 mmol), 1N NaOH (25 mL), and ethanol (5 mL) is heated at reflux for 1.5 h. The reaction mixture is cooled in an ice bath, acidified with aqueous HCl, and the precipitate is collected, rinsed with water and dried to give 0.95 g of 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid.

来源