反应 #2314330

反应方程式

(R,R)-N-mono[4-(diethylamino)salicylidene]-1,2-cyclohexanediamine

4-methoxysalicylaldehyde

→

crude product

(R,R)-N-[4-(Diethylamino)salicylidene]-N′-(4-methoxysalicylidene)-1,2-cyclohexanediamine

溶剂

ethanol

ethanol

反应条件

后处理

1. 1
   温度After the reaction solution has been cooled to room temperature it
2. 2
   浓缩is concentrated to dryness

实验过程

To a suspension of 2.5 g (8.64 mmol) of (R,R)-N-mono[4-(diethylamino)salicylidene]-1,2-cyclohexanediamine in 200 ml of ethanol is added dropwise over the course of 45 minutes at room temperature a solution of 1.3 g (8.64 mmol) of 4-methoxysalicylaldehyde in 200 ml of ethanol. The reaction solution is heated at 60° C. for 4 h. After the reaction solution has been cooled to room temperature it is concentrated to dryness. The crude product obtained is purified by column chromatography (ethyl acetate/methanol 9:1). Yield: 500 mg (14%), reddish orange oil, which slowly crystallizes.

来源