反应 #2314329

反应方程式

(R,R)-N-mono[4-(diethylamino)salicylidene]-1,2-cyclohexanediamine

2,4-dihydroxybenzaldehyde

→

(R,R)-N-[4-(Diethylamino)salicylidene]-N′-(4-hydroxysalicylidene)-1,2-cyclohexanediamine

溶剂

ethanol

反应条件

后处理

1. 1
   温度After cooling to room temperature the resultant brownish orange solution
2. 2
   浓缩is concentrated to dryness

实验过程

To a suspension of 2.5 g (8.64 mmol) of (R,R)-N-mono[4-(diethylamino)salicylidene]-1,2-cyclohexanediamine in 200 ml of ethanol is added dropwise at room temperature over the course of 45 minutes a solution of 1.19 g (8.64 mmol) of 2,4-dihydroxybenzaldehyde. The suspension is heated at 60° C. for 4 h. After cooling to room temperature the resultant brownish orange solution is concentrated to dryness. The crude product (3.5 g) is resolved by column chromatography (ethyl acetate/methanol 9:1). Yield: 570 mg (16%), yellowish orange solid.

来源